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Prenylation of Rab GTPases regulating vesicle traffic by Rab geranylgeranyltransferase RabGGTase requires a complex formed by the association of newly synthesized Rab proteins with Rab-escort-protein REPthe choroideremia-gene-product that is mutated in disease, leading to loss of vision. Rab proteins form a large Do Kendale Lakes women like american men of GTPases that are prenylated at their carboxyl terminus and play a critical role in the vesicular trafficking in eukaryotic cells Peirera-Leal and Seabra, The functional properties of the Mrs6 protein have been recently characterized at the biochemical and molecular levels Anant et al.

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